The developmental biology of genetic Notch disorders

The developmental biology of genetic Notch disorders.

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of congenital disorders in humans. For example, loss of function of Notch results in Adams-Oliver syndrome, Alagille syndrome, spondylocostal dysostosis and congenital heart disorders, while Notch gain of function...

the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation

in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.

Developmental Trajectories in Genetic Disorders

As the cognitive system develops over infancy and through childhood, profound changes in capacity and complexity occur. It is no surprise, then, that neurodevelopmental disorders of genetic origin are emergent over time. Characteristic cognitive profiles arise as neurodevelopmental

Deciphering the Complexity of Cellular, Developmental, and Genetic Biology

Developmental biology. From genetic association to genetic switch.

at which nucleation occurs is determined largely by the size of the nanodroplets present (10). Could the precritical clusters observed by Gebauer et al. also be the result of stabilization of calcium carbonate clusters by another species present as an impurity? This mechanism would provide a basis for stabilizing precritical clusters in a free-energy minimum and does not contradict classical nu...